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Sertraline, citalopram and escitalopram have the lowest potential for drug interactions among the ssris, and are to be preferred in patients on other drugs for general medical conditions or if consideration is given to adding an ssri to other psychotropic medication.
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Discontinuing a ssri, like celexa citalopram , can result in serious problems and should be done under physician supervision.
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In two long-term studies, depressed patients who had responded to citalopram hbr tablets during an initial 6 or 8 weeks of acute treatment fixed doses of 20 or 40 mg day in one study and flexible doses of 20-60 mg day in the second study were randomized to continuation of citalopram hbr tablets or to placebo.
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Due to the risk of qt prolongation, citalopram use should be avoided in patients with certain cardiac conditions, and ecg monitoring is advised if citalopram must be used in such patients.
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